Publications

Peer-reviewed publications

  1. Giardina C, Nakanishi M, Khan A, Kuratnik A, Xu W, Brenner B, Rosenberg DW. Regulation of VDR expression in Apc-Mutant Mice, Human Colon Cancers and Adenomas. Cancer Prev Res (Phila.). 2015. doi: 10.1158/1940-6207.CAPR-14-0371. [In print]
  2. Verma R, Chopra A, Giardina C, Sabbisetti V, Smyth JA, Hightower LE, Perdrizet GA. Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice. Cell Stress & Chaperones. 2015. doi: 10.1007/s12192-015-0574-3. [In print]
  3. Wright KT, Giardina C, Vella AT. Therapeutic targeting of the inflammome. Biochem Pharmacol. 2014;92(2):184-91.
  4. Ononye SN, Vanheyst MD, Giardina C, Wright L, Anderson AC. Studies on the antiproliferative effects of tropolone derivatives in Jurkat T-lymphocyte cells. Bioorg Med Chem, 2014; 289(5):2978-91.
  5. Chopra AS, Anderson A, Giardina CNovel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to Tumor Necrosis Factor-induced apoptosis. J Biol Chem, 2013;289(5):2978-91.
  6. Cao L, Kuratnik A,Xu W, Gibson JD, Kolling F 4th, Falcone ER, Ammar M, Van Heyst MD, Wright DL, Nelson CE, Giardina CDevelopment of intestinal organoids as tissue surrogates: Cell composition and the Epigenetic control of differentiation. Mol Carcinog, 2013;54(3):189-202.
  7. Kuratnik A, Giardina CIntestinal organoids as tissue surrogate for toxicoligcal and pharmacological studies. Biochem Pharm, 2013; 85(12):1721-6.
  8. Dai B, Giardina C, Rasmussen T. Quantitation of nucleosome acetylation and other histone posttranslational modifications using microscale NU-ELISA. Methods in Molecular Biology, 2013; 981:167-76.
  9. Chopra AS, Kuratnik A, Scocchera EW, Wright DL, Giardina CIdentification of novel compounds that enhance colon cancer cell sensitivity to inflammatory apoptotic ligands. Cancer Biology & Therapy, 2013; 14(5):436-49.
  10. Fuller AM, Giardina C, Hightower LE, Perdrizet GA, Tierney CA. Hyperbaric oxygen preconditioning protects skin from UV-A damage. Cell Stress Chaperones, 2013; 18(1):97-107.
  11. Kuratnik A, Senapati VE, Verma R, Mellone BG, Vella AT, Giardina CAcute sensitization of colon cancer cells to inflammatory cytokines by prophase arrest. Biochemical Pharmacology, 2012;83(9):1217-28.
  12. Giardina C, Madigan JP, Godman Tierney CA, Brenner BM, Rosenberg DW. Vitamin D resistance and colon cancer prevention. Carcinogenesis, 2012; 33(3):475-82.
  13. Park HJ, Lee JY, Chung MY, Park YK, Bower AM, Koo SI, Giardina C, Bruno RS. Green tea extract suppresses NF-kB activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis. Journal of Nutrition, 142(1):57-63, 2012.
  14. Rigatti MJ, Verma R, Belinsky GS, Rosenberg DW, Giardina C. Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells. Molecular Carcinogenesis, 2011.
  15. Montrose DC, Horelik NA, Madigan JP, Stoner GD, Wang LS, Bruno RS, Park HJ, Giardina C, Rosenberg DW. Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis. Carcinogenesis, 32(3):343-50, 2011.
  16. Cao L, Gibson JD, Miyamoto S, Sail V, Verma R, Rosenberg DW, Nelson CE, Giardina C. Intestinal lineage commitment of embryonic stem cells. Differentiation, 2011.
  17. Ju J, Naura AS, Errami Y, Zerfaoui M, Kim H, Kim JG, Abd Elmageed ZY, Abdel-Mageed AB, Giardina C, Beg AA, Smulson ME, Boulares AH. Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent protein kinase is critical for VCAM-1 expression upon TNF treatment. Journal of Biological Chemistry, 285(52):41152-60, 2010.
  18. Godman CA, Chheda KP, Hightower LE, Perdrizet G, Shin DG, Giardina C. Hyperbaric oxygen induces a cytoprotective and angiogenic response in human microvascular endothelial cells. Cell Stress Chaperones, 15(4):431-42, 2010.
  19. Godman CA, Joshi R, Giardina C, Perdrizet G, Hightower LE. Hyperbaric oxygen treatment induces antioxidant gene expression. Annals of New York Academy of Sciences, 1197:178-83, 2010.
  20. Verma R, Rigatti MJ, Belinsky GS, Godman CA, Giardina C. DNA damage response to the Mdm2 inhibitor nutlin-3. Biochemical Pharmacology, 79(4):565-74, 2010.
  21. Hosseini-khalili A, Haines DD, Modirian E, Soroush M, Khateri S, Joshi R, Zendehdel K, Ghanei M, Giardina C. Mustard gas exposure and carcinogenesis of lung. Mutation Research, 678(1):1-6, 2009.
  22. Noonan EJ, Place RF, Pookot D, Basak S, Whitson JM, Hirata H, Giardina C, Dahiya R. miR-449a targets HDAC-1 and induces growth arrest in prostate cancer. Oncogene, 28(14):1714-24, 2009.
  23. Rosenberg DW, Giardina C, Tanaka T. Mouse models for the study of colon carcinogenesis. Carcinogenesis, 30(2):183-96, 2009.
  24. Spurling CC, Suhl JA, Boucher N, Nelson CE, Rosenberg DW, Giardina C. The short chain fatty acid butyrate induces promoter demethylation and reactivation of RARbeta2 in colon cancer cells. Nutrition and Cancer. 60(5):692-702, 2008.
  25. Godman CA, Joshi R, Tierney BR, Greenspan E, Rasmussen TP, Wang HW, Shin DG, Rosenberg DW, Giardina C. HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling. Cancer Biology & Therapy, 7(10):1570-80, 2008.
  26. Noonan E, Giardina C, Hightower L. Hsp70B’ and Hsp72 form a complex in stressed human colon cells and each contributes to cytoprotection [Corrected and republished]. Experimental Cell Research, 314(13):2468-76, 2008.
  27. Spurling CC, Godman CA, Noonan EJ, Rasmussen TP, Rosenberg DW, Giardina C. HDAC3 overexpression and colon cancer cell proliferation and differentiation. Molecular Carcinogenesis, 47(2):137-47, 2008.
  28. Noonan EJ, Place RF, Giardina C, Hightower LE. Hsp70B’ regulation and function. Cell Stress Chaperones, 12(4):393-402, 2007.
  29. Nakanishi M, Ménoret A, Belinsky GS, Giardina C, Godman CA, Vella AT, Rosenberg DW. Utilizing endoscopic technology to reveal real-time proteomic alterations in response to chemoprevention. Proteomics Clinical Applications, 1(12):1660-6, 2007.
  30. Ghanei M, Amiri S, Akbari H, Kosari F, Khalili AR, Alaeddini F, Aslani J, Giardina C, Haines DD. Correlation of sulfur mustard exposure and tobacco use with expression (immunoreactivity) of p53 protein in bronchial epithelium of Iranian “mustard lung” patients. Miliatary Medicine, 172(1):70-4, 2007.
  31. Belinsky GS, Rajan TV, Saria EA, Giardina C, Rosenberg DW. Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth. Molecular Carcinogenesis, 46(2):106-16, 2007.
  32. Noonan EJ, Place RF, Rasoulpour RJ, Giardina C, Hightower LE. Cell number-dependent regulation of Hsp70B’ expression: evidence of an extracellular regulator. Journal of Cell Physiology, 210(1):201-11, 2007.
  33. Stevens RG, Swede, H, Jablonski M, Parente M, Tirnauer JS, Heinen CD, Giardina C, Rajan TV, Rosenberg DW, Levine J.  Aberrant Crypt Foci in Persons with a Family History of Colorectal Cancer. Cancer Letters, 248(2):262-8, 2007.
  34. Noonan EJ, Place RF, Giardina C, Hightower LE and Rasoulpour RJ. Cell Number Dependent Regulation of Hsp70B’ expression: evidence of an extracellular regulator. Journal of Cellular Physiology, 210(1):201-11, 2007.
  35. Aizu W, Belinsky GS, Flynn C, Noonan EJ, Boes CC, Godman CA, Doshi B, Nambiar PR, Rosenberg DW and Giardina C. Circumvention and reactivation of the p53 oncogene checkpoint in colon cancer cells. Biochemical Pharmacology, 72:981-991, 2006.
  36. Place RF, Noonan EJ and Giardina C. HDACs and the senescent phenotype of WI-38 cells. BMC Cell Biology, 6:37, 2005.
  37. Place RF and Giardina C. HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity: Down-regulation of proteasome subunit expression stabilizes I kappa B alpha. Biochemical Pharmacology, 70(3):394-406, 2005.
  38. Tong X, Yin L, Joshi S, Rosenberg DW and Giardina C. Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. Journal of Biological Chemistry, 280:15503-9, 2005.
  39. Dong M, Johnson M, Rezaie A, Ilsley JNM, Nakanishi M, Sanders MM, Forouhar F, Levine J, Montrose DC, Giardina C and Rosenberg DW. Cytoplasmic Phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis. Clinical Cancer Research, 11:2265-71, 2005.
  40. Tong X, Yin L, Washington R, Rosenberg DW and Giardina C. The p50-p50 NF-kappaB complex as a cytokine-specific repressor of gene activation. Molecular & Cellular Biochemistry, 265:171-183, 2004.
  41. Tong X, Yin L and Giardina C. Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. Biochemical and Biophysical Research Communications, 317:463-71, 2004.
  42. Dong M, Guda K, Nambiar P, Nakanishi M, Giardina C, Lichtler, and Rosenberg DW. Azoxymethane-induced pre-adipocyte factor 1 (Pref-1) functions as a differentiation inhibitor in colonic epithelial cells. Carcinogenesis, 25:2239-2246, 2004.
  43. Thibodeau M, Giardina C, Helble J, Knecht D and Hubbard AK. Silica induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activity. Toxicological Sciences, 80:34-48, 2004.
  44. Thibodeau M, Giardina C. and Andrea K. Hubbard. Silica induced caspase activation in mouse alveolar macrophages is dependent upon mitochondrial activity and aspartic proteases. Toxicological Sciences, 76:91-101, 2003.
  45. Aizu W, Guda K, Nambiar P, Tong X, Rosenberg DW, and Giardina C. p53 and its co-activator p300 can be inversely regulated in response to DNA damage. Toxicology Letters, 144(2):213-224, 2003.
  46. Brown JD, Strbuncelj M, Giardina C and O’Neill RJ. Interspecific hybridization induced amplification of Mdm2 on double minutes in a Mus hybrid. Cytogenetics & Genome Research, 98(2-3):184-8, 2003.
  47. Place RF, Haspeslagh D*, Giardina C. Induced stabilization of IkappaBalpha can facilitate its re-synthesis and prevent sequential degradation. Journal of Cell Physiology, 195(3):470-8, 2003.
  48. Dong M, Guda K, Nambiar P, Belinsky G, Giardina C and Rosenberg DW. Inverse association between phospholipase A2 and COX-2 expression during mouse colon tumorigenesis.  Carcinogenesis, 24(2):307-15, 2003.
  49. Nambiar P, Giardina C, Guda K, Aizu W, Raja R and Rosenberg DW. Role of the alternating reading frame (p19)-p53 pathway in an in vivo murine colon tumor model. Cancer Research, 62:3667-7, 2002.
  50. Giardina C and Hubbard AK. Growing old with NF-kappaB. Cell Stress & Chaperones, 7:207-212, 2002.
  51. Yin L, Laevsky G and Giardina C. Butyrate suppression of colonocyte NF-kappaB activation and cellular proteasome activity. Journal of Biological Chemistry, 276:44641-6, 2001.
  52. Guda K, Giardina C, Nambiar P, Cui H, Rosenberg DW. Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors. Molecular Carcinogenesis, 31:204-213, 2001.
  53. Hubbard AK, Thibodeau M, and Giardina C. Cellular and molecular mechanisms regulating silica-induced adhesion molecule expression in mice. Journal of Environmental Pathology, Toxicology and Oncology, 20:45-51, 2001.
  54. Place RF, Haspeslagh D*, Hubbard AK, Giardina C. Cytokine-induced stabilization of newly synthesized I(kappa)B-alpha. Biochemical and Biophysical Research Commununication, 18;283(4):813-20, 2001.
  55. Koulich E, Nguyen T, Johnson K, Giardina C, D’Mello SR. NF-kappaB is involved in the survival of cerebellar granule neurons: association of IkappaB-beta phosphorylation with cell survival. Journal of Neurochemistry, 76:1188-1198, 2001.
  56. Crowthers KC, Kline V, Giardina C, Lynes MA. Augmented humoral immune function in metallothionein-null mice. Toxicology and Applied Pharmacology, 166(3):161-72, 2000.
  57. Boulares AH, Giardina C, Inan MS, Khairallah EA, Cohen SD. Acetaminophen inhibits NF-kappaB activation by interfering with the oxidant signal in murine Hepa 1-6 cells. Toxicological Sciences, 55(2):370-5, 2000.
  58. Inan MS, Rasoulpour RJ*, Yin L, Hubbard AK, Rosenberg DW, Giardina C. The luminal short-chain fatty acid butyrate modulates NF-kappaB activity in a human colonic epithelial cell line. Gastroenterology, 118(4):724-34, 2000.
  59. Yin L, Hubbard AK, and Giardina C. NF-kappaB regulates transcription of the mouse telomerase catalytic subunit. Journal of Biological Chemistry, 275:36671-5, 2000.
  60. Inan MS, Place R, Tolmacheva V*, Wang Q-S, Hubbard AK, Rosenberg DW, and Giardina C. IkappaB-beta related proteins in normal and transformed colonic epithelial cells. Molecular Carcinogenesis, 29:25-36, 2000.
  61. Inan MS, Tolmacheva V*, Wang Q-S, Rosenberg DW, and Giardina C. The transcription factor NF-kappaB participates in the regulation of epithelial cell turnover in the colon. American Journal of Physiology Gastrointestinal and Liver Physiology, 279:G1282-G1291, 2000.
  62. Hubbard AK and Giardina C. Regulation of ICAM-1 expression in mouse macrophages. Inflammation, 24(2):115-25, 2000.
  63. Boulares HA, Giardina C, Navarro CL, Khairallah EA, Cohen SD. Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: an inhibition of c-myc expression, NF-kappaB activation, and Raf-1 kinase activity. Toxicological Sciences, 48(2):264-74, Apr 1999. *Toxicological Sciences paper of the year*
  64. Giardina C, Boulares H, Inan MS. NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-alpha and Fas ligation: the role of reactive oxygen species. Biochimica et Biophysica Acta, 1448(3):425-38, 1999.
  65. Giardina C, Inan MS. Nonsteroidal anti-inflammatory drugs, short-chain fatty acids, and reactive oxygen metabolism in human colorectal cancer cells. Biochimica et Biophysica Acta, 1401(3):277-88, 1998.
  66. Giardina C, Lis JT. Dynamic protein-DNA architecture of a yeast heat shock promoter. Molecular and Cellular Biology, 15(5):2737-44, 1995.
  67. O’Brien T, Wilkins RC, Giardina C, Lis JT. Distribution of GAGA protein on Drosophila genes in vivo. Genes and Development, 9(9):1098-110, 1995.
  68. Giardina C, Lis JT. Sodium salicylate and yeast heat shock gene transcription. Journal of Biological Chemistry, 270(18):10369-72, 1995.
  69. Giardina C, Lis JT. Polymerase processivity and termination on Drosophila heat shock genes. Journal of Biological Chemistry, 268(32):23806-11, 1993.
  70. Giardina C, Lis JT. DNA melting on yeast RNA polymerase II promoters. Science, 261(5122):759-62, 1993.
  71. Giardina C, Perez-Riba M, Lis JT. Promoter melting and TFIID complexes on Drosophila genes in vivo. Genes and Development, 6(11):2190-200, 1992.
  72. Giardina C, Wu CW. The identification of two antagonistic activities in a Xenopus oocyte extract that can modulate the in vitro transcription of RNA polymerase III. Journal of Biological Chemistry, 265(16):9121-30, 1990.

Book Chapters

  1. Hubbard AK, Mowbray S, Thibodeau M. and Giardina C. “Silica-induced Inflammatory Mediators and Pulmonary Fibrosis” in Fibrogenesis: Cellular and Molecular Events, Ed. M. Razzaque, Kluwer Academic/ Plenum Publishers, 2005.

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