Colon cancers are frequently infiltrated by immune and inflammatory cells that play a complex role in regulating lesion growth and progression. Understanding how colon cancer cells survive within the inflammatory milieu of a tumor, and developing approaches that increase their sensitivity to inflammatory cytokines, may ultimately lead to novel approaches for colon cancer therapy and prevention. We employ small molecules to elucidate the mechanisms by which colon cancer evade immune surveillance.
Recent publications
- Chopra AS, Anderson A, Giardina C.Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to Tumor Necrosis Factor-induced apoptosis. J Biol Chem, 2013.
- Chopra AS, Kuratnik A, Scocchera EW, Wright DL, Giardina C. Identification of novel compounds that enhance colon cancer cell sensitivity to inflammatory apoptotic ligands. Cancer Biology & Therapy, 2013; 14(5):436-49.