The inter- and intra-cellular signaling events required for maintaining the structure and function of intestinal epithelium, with a focus on those events involved in regulating epithelial cell proliferation and death. Molecular mechanisms of transcription factor regulation by chemical and physical injury.
Recent publications
- Cao L, Kuratnik A,Xu W, Gibson JD, Kolling F 4th, Falcone ER, Ammar M, Van Heyst MD, Wright DL, Nelson CE, Giardina C. Development of intestinal organoids as tissue surrogates: Cell composition and the Epigenetic control of differentiation. Molecular Carcinogenesis Carcinog, 2013. doi: 10.1002/mc.22089.
- Kuratnik A, Giardina C. Intestinal organoids as tissue surrogate for toxicoligcal and pharmacological studies. Biochemical Pharmacology, 2013; 85(12):1721-6.